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GL-26 glioma- bearing mice (55) ic U87 glioblastoma- bearing mice (57) ic GL-261 GBM- bearing mice (54) Murine neuro- blastoma model (53) sc GL-261 tumors in mice (52) C6 glioma model in mice (58) Resultscomments Adenovirally-delivered IL-4 significantly inhibited tumor growth Results in Table 1 Adenovirally-delivered TNF-α coupled with temozolomide prolonged survival HSVIL-4 treatment augmented the oncolytic effect of HSV and improved survival alone or coupled with virally- mediated IL-10 delivery Results in Table 1 HSV-TK infection (with aid of HSV helper virus) resulted in significantly reduced tumor size Virally-delivered IL-2 and IL-12 augmented the antitumor effect of vaccinia virus alone Vaccinia Virus (replication competent) Abbr: ic, intracerebral; sc, subcutaneous.
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